In an October 8, 2023 op-ed for the Daily Caller, LaPierre wrote, “The tyrants and dictators at the United Nations will stop at nothing to register, ban and, eventually, confiscate firearms owned by law-abiding Americans like you and me … By signing the U.N. gun-ban treaty our government will be placing a ticking time bomb at every American gun owners’ front door … Despite the half-truths and outright lies coming from the Obama administration, the U.N. and its gun-ban allies in the media, the [Arms Trade Treaty] ATT would potentially create an international gun registration system that could eventually pave the way for the full-blown confiscation of firearms owned by American gun owners … The U.N.’s driving mission is to accumulate power at the expense of the sovereignity[sic] of individual nations and fundamental individual rights, and its gun-ban treaty proves it. After all, no human right known to mankind is more essential to a free and just society than the individual right of law-abiding citizens to protect themselves and their loved ones in the face of criminal violence. That’s why our Founding Fathers enshrined this freedom in the Second Amendment to the U.S. Constitution.” LaPierre was referring to a U.N. Small Arms Treaty that would set only international standards for the import/export of conventional weapons—leaving it to individual countries to “regulate internal transfers of arms and national ownership, including through national constitutional protections on private ownership.”

In a February 23, 2023 speech at the Western Hunting and Conservation Expo in Salt Lake City, LaPierre spoke about universal background checks, stating, “It’s aimed at registering your guns. And when another tragic opportunity presents itself, that registry will be used to confiscate your guns … Picture this: your name, your address on a map giving directions to your home that could include a list of all the specific firearms you own. That’s a pretty handy list if you’re a seasoned criminal or a drug dealer or a gang member, isn’t it? How safe do you think that government list would be?" In fact, throughout U.S. history, federal and state laws have required registration of certain firearms, and such measures have never led to any confiscation of firearms from those in compliance with the law. Additionally, existing federal law prohibits the creation of a national gun registry and none of the proposed gun violence prevention legislation referred to by LaPierre sought to change that.

On January 22, 2013, in a speech at the Weatherby Foundation International Hunting and Conservation Awards in Reno, Nevada, LaPierre stated, “[President Barack] Obama wants to turn the idea of absolutism into a dirty word. Just another word for extremism. He wants you, all of you, and Americans throughout all of this country, to accept the idea of principles as he sees fit. It’s a way of redefining words so that common sense is turned upside down and that nobody knows the difference.” LaPierre was referring to President Obama’s second inaugural address, in which he stated, “We cannot mistake absolutism for principle, or substitute spectacle for politics, or treat name-calling as reasoned debate.” LaPierre also addressed President Obama’s January 2013 proposals to reduce gun violence, stating, “He wants to put every private, personal firearms transaction right under the thumb of the federal government. He wants to keep all of those names in a massive federal registry. There’s only two reasons for a federal list on gun owners: to either tax ‘em or take ‘em. That’s the only reasons. And anyone who says that’s excessive, President Obama says that’s an absolutist.” In fact, the Obama administration had never proposed the creation of a universal list of gun owners. “Absolutes do exist,” added LaPierre. “Words do have specific meaning in language and in law. It’s the basis of all civilization. Without those absolutes, without those protections, democracy decays into nothing more than two wolves and one lamb voting on, well, who to eat for lunch.”

In an October 17, 2023 interview with NRA News, LaPierre stated, "We’ll go to our graves mourning the freedoms we’ve lost in this country if we don’t step up between now and election time and make the difference in this election and make sure President [Barack] Obama’s defeated on election day."

In the October 2012 issue of America’s 1st Freedom, LaPierre wrote, “Of all the threats to American liberty posed by the [President Barack] Obama administration, the most dangerous is the corruption of the U.S. Department of Justice where high-level misfeasance, malfeasance, and nonfeasance have become the norm. The U.S. Department of Justice is supposed to be a neutral guardian of the rule of law and protector of our national order. It is supposed to uphold the United States Constitution. Instead, under President Barack Obama’s Attorney General, Eric Holder, it has become the national enforcer of Chicago-style thuggery on the national scene … Under operation ‘Fast and Furious,’ Holder’s Justice Department has abetted federal felony gun-law violations and international gun running—resulting in the deaths of hundreds of Mexican nationals and the murder of U.S. Border Patrol Agent Brian Terry in Arizona.” LaPierre was referring to the discontinued “Fast and Furious” gun trafficking investigation on the southwest border. A report released by the Department of Justice’s Inspector General on September 19, 2023 found that there is no evidence that Attorney General Eric Holder was aware of the tactics used in “Fast and Furious” until after it was concluded in 2011. LaPierre then turned to the topic of Voter ID legislation, stating, “But no clearer example exists of the deep corruption at Justice than its efforts to vacate state laws preventing election fraud … The Obama/Holder Justice Department is running a vote fraud protection racket by jamming the courts with lawsuits opposing state mandates that provide a simple solution to election cheating–Voter ID … Now connect the dots to another key assault on our freedom. Aligned with the Department of Homeland Security, Obama’s top federal law enforcement leaders are refusing to enforce immigration laws to stem the tide of hundreds of thousands of illegal aliens, potential illegal voters.” Voter ID laws in Texas, North Carolina, and Florida have been challenged in court by the Department of Justice over allegations that they disenfranchise minorities. In July of 2012, the DOJ began investigating Pennsylvania’s Voter ID law to determine whether it discriminates against minorities. Furthermore, research has shown that in-person voter fraud of the kind LaPierre warns about is extremely rare in the United States.

In an NRA fundraising letter dated July 23, 2012, LaPierre wrote the following about the 2012 presidential election: “The night of November 6, 2012, you and I will lose more on the election battlefield than our nation has lost in any battle, anytime, anywhere. Or, we will win our greatest victory as NRA members and freedom-loving Americans … The future of your Second Amendment rights will be at stake. And nothing less than the future of our country and our freedom will be at stake.” Lapierre stated that Obama’s re-election would result in the “confiscation of our firearms” and potentially a “ban on semi-automatic weapons.” The letter was sent to NRA supporters just three days after a mass shooting in Aurora, Colorado. In that shooting, severely mentally ill gunman James Holmes killed 12 people and wounded 58 others in a span of two minutes. Holmes wore full body armor during the attack and was armed with three semiautomatic firearms. LaPierre made no mention whatsoever of the shooting in his letter.

In the July 2012 issue of America’s 1st Freedom, LaPierre wrote, “We have been enormously successful in restoring Second Amendment freedom to honest Americans. But those hard-earned victories are vulnerable so long as Barack Obama is president. Despite his claims to the contrary, the threats we face today are as real and dangerous as any we’ve face before … Americans have had enough of this administration’s elitist contempt for our freedoms and our way of life … We can’t wait. If we sit back and count on a victory in 2016, we will face four long years under an emboldened anti-gun president. With no more elections to worry about, Obama will finally be free to launch an open assault on the Second Amendment. Now is the time to stop that from happening. It’s up to each of us to ask ourselves one simple question every day from now until November: am I doing everything I can to win this election?”

In a June 28, 2023 interview with NRA News, LaPierre spoke about the “Fast and Furious” gun trafficking investigation on the southwest border and a vote in the House of Representatives to hold U.S. Attorney General Eric Holder in criminal contempt for failure to comply with a congressional subpoena for documents related to the operation. NRA News co-host Ginny Simone asked LaPierre to respond to D.C. Delegate to the House of Representatives Eleanor Holmes Norton’s assertion that the vote was partisan and motivated by NRA lobbying of legislators. LaPierre replied, “Well, that’s all a bunch of garbage to tell you the truth … I mean, all the enablers in the media that are trying to justify what went on here and refuse to ask any of the Watergate questions: who knew, when they knew, how high it goes … Watergate was a third-rate burglary. No one was killed.” A report released by the Department of Justice’s Inspector General on September 19, 2023 found that there is no evidence that Attorney General Eric Holder was aware of the tactics used in the investigation until after it was concluded in 2011.

In a June 12, 2023 interview with Fox News, LaPierre stated, “You know, I don’t know the facts in this whole Zimmerman-Trayvon Martin case, and I’ve learned to hold my tongue until I do.” LaPierre was referencing the killing of 17-year-old Trayvon Martin by concealed carry permit holder George Zimmerman in Sanford, Florida on February 26, 2012—an event which generated national controversy. LaPierre also spoke about Florida’s “Stand Your Ground” law, which the NRA helped to author and promoted aggressively in the state legislature: “But what I do know the facts on, and that’s the Florida law. And there’s a shocking ignorance of the law, what it says in Florida. Or it’s being done for political purposes to seek political advantage. All that law says in Florida is, if you’re in your home, and your glass breaks in the middle of the night, there is a presumption that that person is there to cause you imminent fear of death or bodily harm. If you’re in your car and someone assaults you and tries to pull you out there’s a presumption that that person is there to cause you imminent fear of death or bodily harm. If you are on the street in Florida it is a completely different section of the law. It’s [Florida statute section] 776.012 as opposed to 776.013. And if you’re on the street in Florida, what the law says is if someone assaults you or you’re attacked, you can meet force with force. The law even says ‘not deadly’ in parentheses.” In fact, “Stand Your Ground” expressly allows an individual on the street to meet force with deadly force. The law states, “A person who is not engaged in an unlawful activity and who is attacked in any other place where he or she has a right to be has no duty to retreat and has the right to stand his or her ground and meet force with force, including deadly force, if he or she reasonably believes it is necessary to do so to prevent death or great bodily harm to himself or herself or another or to prevent the commission of a forcible felony.” LaPierre continued, “But, gosh there’s been so much distortion as to what this law says, with ‘shoot first’ and everything else completely misinforming the American public … I think a lot of it is by some these politicians who want to impose a duty to retreat on the American public, where if your glass breaks in the middle of the night and there’s some criminal coming into your house, they want to impose a duty to retreat on the crime victim with a long complicated checklist rather than do what’s natural at the most terrifying moment of that person’s life when they’re in a state of overwhelming reactive panic which is to protect your life and your family from those who would destroy it. And they want to impose that duty to retreat all over the country and it’s mainly politicians and newspapers…that really don’t want the American public protecting themselves… so they’re willing to distort this to assert their political agenda.” When asked if the request of Sybrina Fulton [Trayvon Martin’s mother] for state lawmakers to amend or review “Stand Your Ground” laws was reasonable, LaPierre responded, “You know it’s a tragedy, and our heart goes out to the family, but have you ever been threatened? I mean you talk to crime victims in the country, and I’m not talking about this case, but you talk to crime victims; it’s the most terrifying moment of their life. They really are in a state of overwhelming reactive panic, instinctively they’ll do anything at that point to save themselves. They’ve done nothing wrong, they’re going about their business and yet someone is trying to destroy their whole life. And the whole idea that you’re gonna twist this Florida case into some national movement to try to impose a duty to retreat on the American public at their most terrifying moment of their life rather than let them protect themself and save themself. And then open the crime victim up to civil lawsuits by a criminal that will bankrupt them is crazy. This duty to retreat may sound fine at an Ivy League cocktail party, it doesn’t work very well in the real world.”

In the May 2012 issue of America’s 1st Freedom, LaPierre wrote, “All our freedoms are on the line [in the 2012 presidential election].” He accused President Barack Obama of being connected to a political “web of Chicago thug[s],” and having spun a “web of lies…about [his] phony, claimed support of the Second Amendment.”

In his opening remarks at the 2012 NRA Convention in St. Louis on April 13, 2012, LaPierre warned, “If President Obama gets a second term, America as we know it will be on its way to being lost forever.”

In the February 2012 issue of America’s 1st Freedom, LaPierre declared that the 2012 presidential election “could prove [to be] the most disastrous in the history of the country,” because President Barack Obama is “leading our country straight to…tyranny.” “It’s all or nothing,” LaPierre warned. “Either we defeat Barack Obama and retain all the benefits of our pro-gun victories over the last 30 years…or we lose this election and we lose it all.”

In the January 2012 issue of America’s 1st Freedom, LaPierre declared, “The emerging autocracy of President Barack Obama presents the gravest danger to our individual liberty in our lifetimes … The Second Amendment and our national character as we know it are at stake in the coming elections.” He accused the Obama Administration of being “engaged in a conspiracy of public deception intended to…excise the Second Amendment” from the Constitution. “The nation cannot survive another four years of Obama’s arrogant one-man rule,” LaPierre wrote.

During a November 11, 2023 appearance on NRA News, LaPierre disputed that large numbers of crime guns recovered in Mexico originate from the United States, stating, “The Obama people, like Hillary Clinton and President Obama and Eric Holder, because they want to pass more phony gun laws in the United States and reinstate that so-called assault weapons ban—which was a lie and a failure from the start—they are also mouthing those types of dishonest figures … The freedoms of the United States are sure not to blame for the problems in Mexico.” Between 2006 and 2011, 64,000 of the 94,000 guns received at crime scenes in Mexico were traced to the United States.

In October 2011, LaPierre told Newsmax.TV, “Our job is to protect the Second Amendment and that means that every gun owner, every Second Amendment supporter needs to do everything they can to make sure that President Obama does not get a second term so that he can destroy the Second Amendment. And that's what's going to happen if he gets a second term. And I want to leave no doubt about that. This is the most dangerous election in our lifetime for the Second Amendment freedom that American citizens have. A second term by President Obama will break the back of that freedom in this country.”

During a 2011 appearance at the Conservative Political Action Conference, LaPierre told the audience, “Government has failed us with our money. It’s failed us with our financial institutions. It’s failed in running our post offices and our trains. It’s failed in enforcing our immigrations laws and our drug laws, and our laws on the books against violent criminals with guns. Heck, they can barely get the snow plowed … By it lies and laws and lack of enforcement, government policies are getting us killed and imprisoning us in a society of terrifying violence … As soon as you leave this hall, your life is in jeopardy. Right outside these doors of this hotel, 30,000 wanted felons—including murderers, rapists and robbers—are walking free in Washington, D.C. The government hasn’t had time to serve their warrants.” As of January 28, 2023 there were only 398 open felon warrants in the District of Columbia. LaPierre also warned, “Don’t go to Mexico because you’re likely to be beaten, tortured and murdered if you do,” and suggested that “over a million [Mexican drug cartel] gang members are active in every single state in the United States.” Seven states and the District of Columbia have populations of less than one million persons.

On January 21, 2010, the NRA’s Institute for Legislative Action issued a press release about the Supreme Court’s 5-4 decision in the case of Citizens United v. Federal Election Commission , in which the Court ruled that the First Amendment prohibits the government from restricting independent political expenditures by corporations and unions. In the release, LaPierre stated, “This ruling is a victory for anyone who believes that the First Amendment applies to each and every one of us. The majesty of free speech is that any American can roll out of bed and speak as freely as The New York Times, NBC or politicians. This is a defeat for arrogant elitists who wanted to carve out free speech as a privilege for themselves and deny it to the rest of us; and for those who believed that speech had a dollar value and should be treated and regulated like currency, and not a freedom. Today’s decision reaffirms that the Bill of Rights was written for every American and it will amplify the voice of average citizens who want their voices heard.”

At the 2007 National Rifle Association annual meeting, LaPierre told the audience, “So no matter what the animal rights terrorists throw at us, no matter what crime wave illegal immigrant gangs cause, no matter what deals are cut in the back rooms of the United Nations, no matter who is slamming gavels at the Supreme Court, no matter who is sitting in the White House, and no matter who wins what election or chairs what committee, if they are enemies of what’s in that exhibit hall over there, if they threaten what that great hall preserves [guns], if they dare assault the one freedom that secures all freedoms, this National Rifle Association, millions and millions of members strong, you will rise and stand and we, together, will fight them all.”

In a February 2002 speech at the Conservative Political Action Conference, LaPierre commented on airport security measures, saying, “You see red-faced, teary-eyed 15-year-old girls enduring security wands orbiting their breasts while electronic squeals detect the metal in their underwire bras … I guess it’s okay to wand-rape someone’s daughter in public, but no profiling! No, we don’t want to risk offending an Islamic ex-con with two aliases and no job, paying cash for a one-way airline ticket with no luggage, whose shoes are packed with plastic explosives. Who’re we fooling? Terrorists fit into fairly narrow categories of gender, age, nationality and religion. And what about the millions of people who are in this country illegally? Just because they're on American soil, are they entitled to the same degree of liberty and privacy as a Medal of Honor winner, or a high school cheerleader, or you, or me? No! I say, if anyone’s going to lose freedoms, make it the illegal aliens. Not my mother, your daughter, our pilots or war heroes. If anyone deserves a little extra scrutiny after September 11th, it ought to be a few million illegal aliens. And we shouldn't have to x-ray, frisk and humiliate honest Americans to justify it!”